Another similar problem to using a published game world is running a published adventure, especially these days. You have to assume at least 1 person (if not everyone) has read the adventure or knows something about it.

My advice, mix it up. Change names, add plots/sub-plots, max up some monsters, min down others. Add new elements in the adventure. I'll be running Saltmarsh, but I'm already working on making it a Lovecraftian Horror (or at least themes of this) so there will be foreshadowing from the start of evil fish-men and their ancient masters out of time, in their cyclopean city beneath the waves.

I'm thinking Dagon if anyone is familiar with that story. If not I recommend reading it, it's a classic Lovecraft tale.